Profhilo: Bio-Remodelling, Results & Cost in Phitsanulok 2026

What is Profhilo? Why it is not a filler

When a patient comes in and asks me about Profhilo, the thing I hear most often is, "Doctor, it is a kind of filler, right? Will my face look puffy after?" I understand that worry completely, because the moment people hear "something injected into the skin," they immediately picture a fuller, plumper face.

Let me ask you to set that worry aside for a moment, because Profhilo works in a completely different way from filler. The simple way I explain it: ordinary filler is like "adding a cushion where things have hollowed out" so the area looks full again, while Profhilo is like "watering and nourishing the whole garden bed" so your skin becomes dewy, bouncy and healthy from the inside out.

To put it in slightly technical terms, Profhilo is a very pure, high-concentration hyaluronic acid (HA), made with a technology called NAHYCO that binds two sizes of HA together without using a chemical cross-linker (BDDE). Its goal is not to build up facial structure, but rather what is called bio-remodelling — improving the structure and quality of your skin from within, focusing on hydration, bounce and firmness rather than changing the shape of your face.

How Profhilo works in your skin (no medical degree needed)

The next question patients usually ask is, "But what does it actually do in my skin, doctor? How can just HA make skin firmer?" I love this question, because once you understand the mechanism, you can decide for yourself whether it is right for you.

Normally, the HA already in your skin acts like a "water-holding sponge," keeping skin plump, bouncy and healthy. But as we age, the HA and collagen in our skin decline, so skin starts to look dry, dull and saggy. Profhilo helps here in three main ways.

1. Deep hydration

High-concentration HA draws water into the skin layers, making skin plump, bouncy and dewy from within — not the surface-level shine you get from a topical cream.

2. Wide spread

Thanks to NAHYCO technology, the Profhilo flows and spreads well, so just a few injection points are enough to nourish a wide area — without staying lumped in one spot the way filler does.

3. Prompting your skin to make its own collagen and elastin

This is the heart of what bio-remodelling means. Profhilo stimulates your skin cells (especially the fibroblasts) to produce new collagen and elastin, so the skin gradually becomes denser and firmer on its own, naturally — not just temporarily dewy.

Once you see the picture, you understand that Profhilo does not "add something to make you puffy" — it "restores skin quality" so you look healthy again. That is why its results look natural, and why people around you tend to feel you look "fresher" rather than being able to tell you "had something done."

How Profhilo differs from filler and skin boosters

This is where patients get the most confused, and I want it to be clear before you decide, because these three look similar (all injected into the skin, all containing HA) — but their "goals" are completely different. Let me lay it out in a simple table, then explain further.

The summary I like to give patients is this: if you want to "reshape your face" or fill a hollow, filler is the answer. If your skin is just "dry and dehydrated," a skin booster is enough. But if you feel your "skin is losing its bounce, starting to sag a little, and looking tired all at once" and you want both dewiness and firmness while still looking like yourself — Profhilo is the group that fits that. In the end, a doctor still needs to look at your actual skin before knowing which one suits you best.

Who Profhilo suits, and who should consult first

Many people, reading this far, start to wonder, "So is my kind of face right for it?" Let me describe the groups that tend to do well with Profhilo.

When you see results, how many sessions, how long they last

Almost every patient asks, "Will I see results after just one session, doctor?" Let me answer honestly: Profhilo is about "gradually restoring the skin," not something you see in an instant the way adding volume works. So a little patience gives you a worthwhile result.

Standard protocol: usually 2 sessions, 1 month apart

Most plans are 2 sessions, about 1 month (around 4 weeks) apart, so the skin can gradually build collagen and remodel step by step. Completing the full course matters more than doing one session and expecting full results.

The timeline of gradual results

Generally, patients start to feel their skin is "dewier and fresher" in the first 1-2 weeks, while the "bounce and firmness" become clearer gradually and peak around 4-6 weeks after completing the course, because collagen takes time to form.

How long it lasts and when to repeat

Results typically last about 6 months, depending on each person's skin condition, age and self-care. After that I usually recommend repeating to maintain the effect roughly every 6-9 months — like "watering a plant" regularly, so the skin stays looking healthy continuously.

1. Sessions 1–2 (1 month apart) the standard protocol of 2 sessions, about 4 weeks apart
2. First 1-2 weeks skin starts to look dewier and fresher
3. 4-6 weeks after the course bounce and firmness peak
4. About 6 months results hold, depending on each person's skin
5. Every 6-9 months repeat to maintain the effect

Is Profhilo safe? What are the side effects

I know that once you read about injections, many people start to worry: "Does it hurt? Is it dangerous? Will something go wrong?" Let me tell you everything honestly, because knowing in advance is the best way to prepare and protect yourself.

The good news is that Profhilo is considered very safe, because it is pure HA that does not use a chemical cross-linker (BDDE) — the substance some people worry about in certain fillers. So most side effects are minor and temporary, such as:

• Mild redness, swelling or bruising at the injection point — usually improves on its own within a few hours to a few days
• Small bumps at the injection points — normal for this technique, and they usually settle on their own within 24-48 hours
• A slight tightness or tenderness at first — resolves on its own in a short time

As for serious complications such as vascular problems, they are very rare and are mainly linked to "injection technique and placement" — which is exactly why I emphasize the person doing the injecting even more than the product itself.

What I want to say honestly: genuine product and injection technique

Now we come to the part I want to talk to you about most candidly, because whether Profhilo is truly safe and effective does not depend on the "name Profhilo" alone — it depends on two important things that many people overlook.

The first is "genuine, FDA-registered product." When something is popular and high-priced, imitations or unregistered products slip into the market. With these, no one can certify what is inside, whether it is clean and sterile, or whether the dosage is correct. I want you to feel free to ask to see the box, see the registration number, and check it at oryor.com, the FDA site, anytime. A clinic that genuinely intends to care for you will be glad to show you in person.

The second is "technique and injection points." Profhilo has a specific injection technique called BAP (Bio-Aesthetic Points) — choosing injection points that are safe and spread well, so the product reaches and nourishes a wide area with less pain while avoiding risky locations. Injecting at the right points according to this principle is what separates "good and safe results" from "risks that should never happen." So the person injecting you should be a doctor who truly understands facial anatomy.

I say this not to scare you, but because I want you to have the right questions to use when choosing — wherever you have it done. Your safety always matters more than the cheapest price.

How much does Profhilo cost? Is it worth it

Price is the thing patients want to know first, and I understand that well. But let me not toss out a number out of context, because a price given without seeing your actual case usually leads to misunderstanding. Let me explain what the cost of Profhilo depends on, so you can decide better.

Factors that make the price differ

• Whether it is genuine and FDA-registered — genuine, verifiable product naturally costs differently from unregistered product (which I absolutely do not recommend touching)
• The number of sessions in the course — the standard protocol is usually 2 sessions, so the price should be thought of per course, not per single session
• The area treated — face, neck, or the back of the hands use different amounts and care
• Who assesses and injects — having a doctor assess, choose genuine product, and inject with the right technique is what is most worthwhile in the long run

Is it worth it — how I see it

I want you to look at "long-term value" rather than the cheapest number. Profhilo done by a doctor, using genuine product and injected at the right points, gives you skin that looks naturally healthy and safe — whereas something unusually cheap usually comes with risks that may cost you far more later. If you want to know the price that truly fits your case, message Dr. Time on LINE. I will assess and advise based on your skin condition. Consultation is free, with no pressure.

Profhilo in Phitsanulok — Depry Clinic

If you live in Phitsanulok or a nearby province and want to bring your skin back to being dewy, bouncy and naturally healthy with Profhilo, Depry Clinic in Phitsanulok, Thailand would be glad to take care of you.

Here, Dr. Time personally assesses and cares for every case, starting by looking at your actual skin to see whether Profhilo suits you, or whether another option would address the problem better. I use only genuine, verifiable product, inject with a safety-focused technique, and follow up on results continuously — because here, the people who come in are seen as "patients," not "customers." I want you to get what truly suits you, not what is easiest to sell.

Want to start caring for your skin the way that means you do not have to be afraid — because a doctor genuinely assesses and looks after every step? Message Dr. Time anytime. Consultation is free, at no charge.

Frequently asked questions

What is Profhilo? Is it a filler?

Not a filler in the way most people picture it. Profhilo is a high-concentration hyaluronic acid (HA) designed for bio-remodelling — improving the structure and quality of your skin from within, focusing on hydration, bounce and collagen/elastin stimulation. It is not meant to build up facial structure or change your face shape the way ordinary fillers do.

How is Profhilo different from regular HA filler and skin boosters?

Ordinary HA filler is a firm gel that stays in one spot to add volume, while a typical skin booster mainly adds water to make skin dewy. Profhilo uses NAHYCO technology that lets the HA spread widely and also prompts your skin cells to produce their own collagen and elastin — so you get both hydration and firmness at once. It suits skin that is starting to sag and look tired, not just dehydrated.

Who is Profhilo right for?

People with mild to moderate early sagging, tired or dehydrated skin, dull skin that has lost its bounce, shallow fine lines, and anyone aged 25 and up who wants preventive skin care and a naturally healthy look without making the face fuller. People not yet ready for filler often prefer this option. Those who are pregnant, breastfeeding, or who have inflamed or infected skin at the injection site should always consult a doctor first.

How many sessions does Profhilo need, when do results show, and how long do they last?

The standard protocol is usually 2 sessions, about 1 month (4 weeks) apart. Hydration starts to show in the first 1-2 weeks, while firmness and bounce build gradually and peak around 4-6 weeks after completing the course. Results typically last about 6 months, after which a repeat treatment every 6-9 months maintains the effect, depending on each person's skin.

Is Profhilo safe? What are the side effects?

It is considered very safe because it is pure HA that does not use a chemical cross-linker (BDDE). The most common side effects are mild redness, swelling or bruising, or small bumps at the injection points, which usually settle on their own within 24-48 hours. Serious complications such as vascular problems are very rare and are linked to injection technique — which is why having a doctor assess and inject at the correct points matters so much.

Does the Profhilo used need to be FDA-registered, and how do I check it is genuine?

It should be registered with Thailand's FDA and verifiable. You can ask to see the box and the registration number before treatment, then check it at oryor.com, the website of Thailand's Food and Drug Administration. A clinic that meets proper standards will always be happy to show you the genuine product in front of you. Unregistered product or an unusually low price is a warning sign.

How much does Profhilo cost, and why does the price differ from place to place?

The price depends on several factors: whether it is genuine and FDA-registered, the number of sessions in the course (usually 2), the area treated (face, neck, back of the hands), and most importantly who assesses and injects it. I recommend looking at long-term value and safety rather than the cheapest number. Message Dr. Time on LINE for an assessment and a price that fits your case.

Where can I get Profhilo in Phitsanulok?

At Depry Clinic in Phitsanulok, Thailand, Dr. Time personally assesses and cares for every case — starting by looking at your actual skin to see whether Profhilo suits you or another option would be better, choosing genuine verifiable product, injecting with a safety-focused technique, and following up on results. Because here, the people who come in are treated as patients, not customers.

References & how to verify

I want you to be able to check the information I use for yourself — here are credible references on the safety of skin-injectable substances and on choosing aesthetic procedures safely:

• PubMed Central (PMC) — academic work on the safety of skin-injectable substances: pmc.ncbi.nlm.nih.gov
• U.S. Food and Drug Administration (FDA) — information on dermal fillers (soft tissue fillers): fda.gov
• NHS (United Kingdom) — advice on having cosmetic procedures safely: nhs.uk
• Thai Food and Drug Administration (อย.) — product and registration verification system: oryor.com