Rejuran (Salmon DNA / PN Skin Booster): Results & Cost in Phitsanulok 2026

What is Rejuran? Why it comes from salmon DNA

When patients walk in asking about Rejuran, the first question I hear most often is, "Doctor, I heard it's made from salmon DNA — that sounds strange, is it safe?" I understand that feeling completely. The moment people hear "fish DNA," many feel an instant flicker of doubt.

Believe it or not, it really does come from salmon DNA — and that's exactly why it works so well on human skin. Let me start by explaining that the DNA of many living things shares a similar basic structure, and salmon DNA is very similar to human DNA. So your body accepts it well, without treating it as something foreign.

To put it in slightly technical terms, Rejuran is a polynucleotide (PN), also known as PDRN (polydeoxyribonucleotide), extracted and purified from salmon DNA. The best-known version is Rejuran Healer. Its goal isn't to plump up the contours of the face like a filler, but to "prompt the skin to repair and rejuvenate itself from within" — focusing on skin quality, bounce, and the strength of the skin tissue rather than reshaping the face.

How Rejuran works in your skin (no medical degree needed)

The next thing patients usually wonder is, "So what does this fish DNA actually do in my skin, doctor — why does it make skin better?" I love this question, because once you understand the mechanism, you can decide for yourself whether it's right for you.

Let me explain it in plain terms first. Picture skin that's dull, delicate, or has been through damage (from sun, age, or lasers) like a fabric that's starting to fray and lose its elasticity. What Rejuran does isn't "stuffing filling in" — it's "sending a signal to the skin cells to start repairing and weaving new fibers" on their own. It works mainly in these ways:

1. Prompts the skin to repair its own tissue

PDRN binds to a receptor in the skin (the adenosine A₂A receptor) that acts like a "switch," telling cells to divide and repair tissue. So the skin gradually recovers from within, not just looking good on the surface.

2. Builds new collagen and elastin

It stimulates fibroblasts to produce type 1 and type 3 collagen, as well as elastin, making skin thicker, bouncier, and naturally softening the look of fine lines.

3. Reduces inflammation and improves circulation

PDRN has anti-inflammatory effects and helps stimulate the formation of tiny capillaries, so skin that flushes easily, gets irritated easily, or is delicate gradually calms down and grows stronger. This is why many people also use Rejuran to care for skin after lasers or for sensitive skin.

Once you picture it, you'll understand that Rejuran doesn't "fill anything to make it bulge" — it "rejuvenates skin quality from its own depths." The results look natural, and the people around you tend to feel that your "skin looks better, brighter" rather than being able to tell you've had something done.

Rejuran vs. HA skin boosters and collagen biostimulators

This is where patients get most confused, because all three of these are "substances injected into the skin" — yet their "goals" are completely different. Let me lay it out in a simple table, then explain further.

The summary I like to give patients is this: if your skin is "mainly dry and dehydrated," an HA skin booster fits the bill. If you're "starting to sag and want firmness," a collagen biostimulator is more on point. But if you feel your "skin is dull, delicate, uneven, easily irritated, and you want it to come back strong and able to repair itself" — Rejuran is the group that answers exactly that. And in many real cases, I use several of these together depending on the problem. In the end, a doctor needs to examine your actual skin before saying which one suits you best.

Who Rejuran suits, and who should consult first

Many people, reading this far, start to wonder, "So does my kind of skin suit it?" Let me tell you which groups tend to do well with Rejuran.

• Dull, lackluster skin that lacks bounce — no matter how much cream you use, the skin still doesn't feel bright or smooth
• Fine lines and enlarged pores — especially on the cheeks, around the eyes, and forehead
• Wanting to care for the eye area — fine lines under the eyes, thin skin around the eyes (there's a dedicated under-eye formula)
• Delicate, sensitive, easily reddened skin — wanting gentle rejuvenation and less irritation
• People who have just had a laser or procedure — wanting the skin to recover faster and grow stronger
• Acne scars or shallow acne pits — wanting smoother skin

As for the group I'd like to "consult a doctor first" — this isn't a ban, but it needs an individual assessment — that includes people who are pregnant or breastfeeding, those with inflamed, infected, or actively inflamed-acne skin at the injection site, and, what I especially emphasize, anyone with a history of fish or seafood allergy must always tell the doctor first, because Rejuran is made from salmon DNA. Assessing before treatment is what helps you get the right result, as safely as possible.

When you'll see results, how many sessions, how long they last

The question almost every patient asks is, "Will I see results from just one session, doctor?" Let me answer honestly: Rejuran is about "gradually repairing and rejuvenating the skin," not something that shows instantly like adding contour. So a little patience pays off well.

The usual protocol: typically a course

Most of the time it's planned as a course, done about 2-4 weeks apart per session. Many cases start to see clearer changes after 2-3 sessions, because the skin needs time to repair and build collagen step by step. Completing the full course matters more than doing one session and expecting full results.

A timeline of results that come gradually

Generally, patients start to feel their skin "looks brighter and more hydrated" in the first few weeks, while "smoothness and bounce" become clearer as more collagen is built. Research has found that around 4 weeks after treatment, skin hydration improved by about 14.69% and elasticity by about 21.78%, which reflects results that come gradually but are tangible.

1. First few weeks skin starts to look brighter and more hydrated
2. Around 4 weeks skin hydration and elasticity improve
3. After 2-3 sessions (2-4 weeks apart) clearer changes appear as more collagen is built

How long it lasts and when to repeat

Results depend on each person's skin condition, age, and self-care. After completing a course, I usually recommend repeating periodically to maintain results — like "ongoing nourishment" to keep skin consistently strong, rather than waiting until the skin grows dull and then coming back to start over.

Is Rejuran safe? What are the side effects

I know that once you read about injections, many people start to worry: "Does it hurt? Is it dangerous? Will something go wrong?" Let me tell you everything as it is, because knowing is the best way to prepare your mind and protect yourself.

The good news is that Rejuran is considered very safe, because salmon-derived PDRN is well tolerated by the human body, so serious allergic reactions are very rare. Most side effects are minor and temporary, such as:

• Mild swelling, redness, or slight bruising at the injection points — usually improves on its own within a few hours to a few days
• Small papules at the injection points early on — this is normal for this technique and usually settles on its own within a few days
• A slight feeling of tightness or soreness early on — resolves on its own in a short time (a numbing cream is usually applied before injecting for more comfort)

What I want to say honestly is that the "long-term" safety data for the PDRN group is still limited and under further study. That doesn't mean it's unsafe — it means that doing it with a doctor who assesses you first, using genuine product, and following up on results is the most prudent path.

What I want to tell you honestly: genuine product and fish allergies

Now for the part I want to discuss with you most sincerely, because whether Rejuran is truly safe and effective doesn't depend on the "Rejuran name" alone, but on two important things many people overlook.

The first is "genuine product registered with the FDA." When something is famous and pricey, imitations or unregistered products inevitably slip into the market. No one certifies what's inside these — whether they're clean and sterile, or whether the amount of substance is correct. I want you to feel free to ask to see the box, check the registration number, and verify it on the FDA's site at oryor.com anytime. A clinic that genuinely intends to care for you will be happy to show you in person.

The second is "people allergic to fish or seafood must tell the doctor," because Rejuran is made from salmon DNA. Although the purification process greatly reduces allergenic proteins and reactions are very rare, if you have a history of fish or seafood allergy, I want you to tell me first every time, so I can assess the risk individually and decide together with you whether you should have it or choose a safer option. Telling the truth about your health history is what protects you best.

I bring this up not to frighten you, but because I want you to have the right questions to use when choosing — wherever you go. Your safety always matters more than the cheapest price.

How much does Rejuran cost? Is it worth it

Price is the thing patients want to know first, and I understand that well. But let me hold off on tossing out a floating number, because a price given without seeing the actual case usually leads to misunderstanding. Let me explain what Rejuran's price depends on, so you can decide better.

Factors that make the price differ

• Whether it's genuine and FDA-registered — verifiable genuine product naturally has a different cost from unregistered product (which I would never recommend touching)
• Number of sessions in the course — Rejuran is usually done as a course, so the price should be thought of per course, not per single session
• Formula and treatment area — for example, a dedicated under-eye formula or treating the whole face uses different amounts and care
• Who assesses and injects — having a doctor take your history, assess, choose genuine product, and inject with the right technique is what's most worthwhile in the long run

Is it worth it? How I see it

I'd like you to look at "long-term value" rather than the cheapest number. Rejuran done with a doctor, using genuine product and injected in the right places, gives skin that genuinely rejuvenates and stays safe — whereas suspiciously cheap product often comes with risks that may cost more later. If you want a price that matches your actual case, message Dr. Time on LINE. I'll assess and advise based on your skin condition. Free consultation, no pressure.

Rejuran in Phitsanulok — Depry Clinic

If you live in Phitsanulok or a nearby province and want to bring your skin back to smooth, bouncy, strong, and rejuvenated from within with Rejuran, Depry Clinic (Phitsanulok, Thailand) would be glad to look after you.

Here, Dr. Time assesses and cares for every case personally, starting by examining your actual skin and taking a history (including fish/seafood allergies) to determine whether Rejuran suits you or whether another option fits your problem better. I use only genuine, verifiable product, inject with safety-focused technique, and follow up on results continuously, because here we see the people who come in as "patients," not "customers." I want you to get what truly suits you, not what's easiest to sell.

• Doctor: Dr. Time — Board certification in Aesthetic Medicine, AAAM, USA · Anti-Aging Medicine, ABAARM, USA · PhD, University of Leeds, UK
• Location: Chaiyanuphap Road, Phitsanulok (across from Hatsanan Hotel)
• Phone: 063-542-9664

Want to start caring for your skin in a way you don't have to be afraid of, because a doctor genuinely assesses and looks after you at every step? Message Dr. Time anytime. The consultation is free, at no cost.

Frequently asked questions

What is Rejuran, and is it really made from salmon DNA?

Yes, it really is. Rejuran is a polynucleotide (PN/PDRN) extracted and purified from salmon DNA. Because the structure of salmon DNA is very similar to human DNA, the body accepts it well. Its main job is not to plump or fill the face, but to prompt the skin to "repair itself" from within, restoring skin quality, bounce, and softening fine lines.

How is Rejuran different from HA skin boosters and collagen biostimulators?

HA skin boosters mainly add water for a dewy, hydrated look, while collagen biostimulators focus on building collagen for firmness. Rejuran works from a different angle: it "repairs and rejuvenates skin tissue," stimulating fibroblasts to make collagen and elastin, reducing inflammation, and it suits delicate, dull, or post-laser skin especially well. They solve different problems, so a doctor needs to examine your actual skin before deciding which fits you.

Who is Rejuran suitable for?

People with dull, tired skin that lacks bounce, fine lines, enlarged pores, or uneven texture; those who want to care for the eye area; and people with delicate or sensitive skin who want gentle rejuvenation, including those who have just had a laser or procedure and want faster recovery. People who are pregnant, breastfeeding, have inflamed or infected skin at the injection site, or are "allergic to fish/seafood" should always consult a doctor first.

How many Rejuran sessions are needed, when will I see results, and how long do they last?

The usual protocol is a course of sessions; many cases start to see clearer changes after 2-3 sessions, spaced about 2-4 weeks apart. Because Rejuran gradually repairs and builds collagen, results come step by step. Research has found skin hydration and elasticity improve roughly 4 weeks after treatment, after which maintenance sessions are usually done periodically to sustain results based on each person's skin.

Is Rejuran safe? What are the side effects?

It is considered very safe, because salmon-derived PDRN is well tolerated by the body. The most common side effects are mild swelling, redness, slight bruising, and small "papules" at the injection points early on, which usually settle on their own within a few days. Serious allergic reactions are very rare. Long-term safety data is still limited and under further study, so seeing a doctor who assesses you first and uses genuine product is what matters most.

Can people allergic to fish or seafood have Rejuran?

You must always tell your doctor first, because Rejuran is made from salmon DNA. Although the purification process greatly reduces allergenic proteins and reactions are very rare, anyone with a history of fish or seafood allergy should inform the doctor so the risk can be assessed individually. That way the doctor can decide together with you whether it suits you or whether a safer option is better.

How much does Rejuran cost, and why does it vary between places?

The price depends on several factors: whether it is genuine and FDA-registered, the number of sessions in the course, the formula used (such as one for the under-eye area), the treatment area, and crucially, who assesses and injects it. I advise looking at long-term value and safety rather than the cheapest number. Message Dr. Time on LINE for an assessment and a price that matches your specific case.

Where can I get Rejuran in Phitsanulok?

At Depry Clinic in Phitsanulok, Dr. Time assesses and cares for every case personally, starting by examining your actual skin and taking a history of fish/seafood allergies to see whether Rejuran suits you or another option is better. We choose genuine, verifiable product, inject with safety-focused technique, and follow up on results, because here we see the people who come in as patients, not customers.

References & how to verify

I want you to be able to check the information I use for yourself — here are credible references on polynucleotides (PN/PDRN), the safety of skin-injectable substances, and choosing aesthetic procedures safely:

• PubMed — Phase 3 study evaluating the efficacy and safety of Rejuran for reducing wrinkles: pubmed.ncbi.nlm.nih.gov
• PubMed Central (PMC) — Academic paper on the safety of skin-injectable substances: pmc.ncbi.nlm.nih.gov
• U.S. Food and Drug Administration (FDA) — Information on dermal fillers (soft tissue fillers): fda.gov
• NHS (United Kingdom) — Advice on having cosmetic procedures safely: nhs.uk
• Thai FDA (อย.) — Product and registration verification system: oryor.com