- How long does Karisma really last
- Why it's shorter than the PLLA/PCL group
- Results timeline — 2 phases
- Comparing longevity with other options
- What makes results last shorter or longer than they should
- How to make results last as long as possible
- Do you need to come back for top-ups often
- Are 6–12 month results worth it
- Consult about Karisma in Phitsanulok — de Pry Clinic
- Frequently asked questions
- References
The results of Karisma last roughly 6–12 months (18 months in some people), which is shorter than collagen stimulators in the PLLA/PCL group, because Karisma uses Rh-Collagen + HA that focuses on "restoring skin quality" rather than laying down a semi-permanent scaffold. But how long it actually "lasts" still depends on your skin condition, age, and self-care. In this article, Dr. Time will walk you through the results timeline, tell you the factors that make it shorter or longer, and explain how to care for your skin so results last as long as possible, in an easy-to-understand way.
How long does Karisma really last
A question patients often ask me is, "How many months does Karisma last?" Based on the data and real-world experience, my answer is — generally around 6–12 months, and in some people whose skin responds well and who take good care of themselves, it may last up to 18 months.
This figure is shorter than polymer collagen stimulators such as Sculptra or Ellanse, but there's a reason for it, which I'll explain next. If you'd first like to know what Karisma is, try reading the "What is Karisma" article alongside this one.
Why it's shorter than the PLLA/PCL group
Got questions? Dr. Time offers personalized, honest consultations — no upselling.
Consult via WhatsAppThe reason lies in the "material used." Sculptra (PLLA) and Ellanse (PCL) are polymers that break down very slowly, so they act as a scaffold that stimulates the body to produce collagen continuously for years. Karisma, on the other hand, uses Rh-Collagen (recombinant collagen) + HA that focuses on restoring skin quality and hydration, which the body gradually uses up naturally.
Put simply, Karisma is like "deep skin restoration and rejuvenation" that gives good, natural-looking results but requires ongoing care — it's not "laying down a scaffold that lasts for years." There is research studying recombinant Type III collagen in skin rejuvenation that found good results within the study period.
Results timeline — 2 phases
- First phase (the early period after treatment) — HA helps the skin look hydrated and plumper, and you can see brightness fairly quickly.
- Later phase (the following weeks) — Rh-Collagen helps restore and stimulate collagen production, so skin quality gradually improves, becoming smoother and more elastic.
- Maintenance period (the months after) — results hold according to your self-care, before gradually fading as you approach the end of the cycle, which is when many people plan to come back for a top-up.
Comparing longevity with other options
| Option | Approximate longevity | Main focus |
|---|---|---|
| HA filler | ~6 months–1 year | Adding volume to specific areas |
| Karisma (Rh-Collagen+HA) | ~6–12 months (some 18) | Restoring skin quality, hydration |
| Radiesse (CaHA) | ~12–18 months | Volume + firmness |
| Sculptra (PLLA) | ~18–25 months | Firming the whole face, natural |
| Ellanse (PCL) | ~1–4 years | Firmness that lasts the longest |
As you can see, Karisma falls in the group with moderate longevity, but its strength isn't "lasting the longest" — it's "skin quality that's restored in a natural way."
What makes results last shorter or longer than they should
Tends to make results last longer
- Doing a course as recommended by your doctor
- Applying sunscreen consistently
- Getting enough rest, drinking enough water, good basic skincare
- Not smoking, keeping a stable body weight
Tends to make results last shorter
- Regular intense sun exposure without sun protection
- Smoking, getting little rest
- A metabolism faster than average
- Doing it once and not following up with care
How to make results last as long as possible
- Do a course as recommended by your doctor so skin quality improves and results are maintained continuously.
- Apply sunscreen every day — the sun destroys collagen, and sun protection helps preserve the results Karisma has built.
- Get enough rest and drink enough water to keep your skin healthy.
- Avoid smoking and extreme weight loss that undermine collagen.
- Come back for top-ups on an appropriate cycle and let your doctor help plan it.
I'd like you to see Karisma as deep skincare done in cycles, rather than a one-time treatment. People who do it continuously and maintain good basic skincare often feel that their skin's foundation keeps improving over the long term, not just looking good cycle by cycle.
Do you need to come back for top-ups often
Because results last around 6–12 months, many people choose to come back for top-ups 1–2 times a year to keep skin quality consistent. The right frequency depends on each person's skin condition and satisfaction, and I'll help plan a care cycle that suits you — not a fixed schedule that's the same for everyone.
Many people worry that once Karisma wears off, their skin will "sag" more than before — that's not the case. As the results gradually fade, your skin returns close to its original point according to your real age; it doesn't get worse because of having done Karisma. So you can decide with peace of mind whether to continue or take a break.
- It lasts around 6–12 months (some 18), shorter than the PLLA/PCL group because it focuses on restoring skin quality
- Actual longevity depends on your skin condition, lifestyle, and self-care
- See it as long-term skincare done in cycles, not a one-time treatment
Are 6–12 month results worth it
It depends on your goal. If you want to restore skin quality in a natural way and are fine with ongoing care, then Karisma is worth it in that sense. But if you want results that last for years without wanting to repeat treatment, the PLLA/PCL group may suit you better. You can read more about pricing and value in the "How much does Karisma cost" article.
Consult about Karisma in Phitsanulok — de Pry Clinic
At de Pry Clinic, Phitsanulok, Dr. Time will help you plan a Karisma care cycle that suits your skin condition and lifestyle, always looking at your actual skin and listening to your concerns first, rather than focusing on selling a fixed package. Some people may be better suited to filler or another collagen stimulator that lasts longer, and I'll tell you straight based on your goals.
I use only products that can be verified, inject them myself, and provide continuous care, because being treated close to home has the advantage of making top-ups and follow-ups convenient. If you're still unsure, feel free to come in and talk first.
Frequently asked questions
Here I've gathered the questions about Karisma's longevity that patients ask me most often, with my answers right here.
How long does Karisma last?
Around 6–12 months, and 18 months in some people, depending on skin condition, age, metabolism, and self-care.
Why is it shorter than Sculptra/Ellanse?
Because Sculptra/Ellanse are slow-degrading polymers that stimulate collagen for years, whereas Karisma uses Rh-Collagen+HA that focuses on restoring skin quality, which the body uses up naturally.
How many days until you see results?
In the first phase, the skin becomes hydrated and plumper from HA fairly quickly; in the later phase, skin quality improves from Rh-Collagen in the following weeks.
What makes results last shorter?
Intense sun, no sun protection, smoking, little rest, a fast metabolism, and doing it once without following up with care.
How do you make it last as long as possible?
Do a course, apply sunscreen, get enough rest, avoid smoking, and come back for top-ups on the cycle your doctor recommends.
Do you need top-ups often?
Many people top up 1–2 times a year to maintain results; the frequency depends on skin condition and satisfaction, so let your doctor plan it for you.
Once it wears off, is the skin worse than before?
No, the skin returns close to its original point according to age; it doesn't get worse because of having done Karisma.
Are 6–12 month results worth it?
Worth it if you want to restore skin quality in a natural way and are fine with ongoing care; if you want it to last for years, you might choose the PLLA/PCL group.
References
The academic information I used to write this article comes from the following sources. Feel free to click and read the originals yourself:
- PubMed (Randomized Controlled Trial) — the use of recombinant Type III collagen for facial skin rejuvenation and the results obtained: pubmed.ncbi.nlm.nih.gov
- PubMed — recombinant Type III collagen microgel, an injectable for rejuvenating aging skin: pubmed.ncbi.nlm.nih.gov
- PubMed — injectable recombinant Type III collagen and photo-aged skin: pubmed.ncbi.nlm.nih.gov
- Thai FDA (Food and Drug Administration) — check products registered in Thailand yourself: oryor.com
Want to know how long Karisma can last on your skin, and how to care for it and time your top-ups? Let Dr. Time at de Pry Clinic, Phitsanulok plan it for you before you decide.
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